Neurobiology of Disease Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia
نویسندگان
چکیده
Bo Chen,1,3 Beth Friedman,2 Michael A. Whitney,2 Jessica A. Van Winkle,1 I-Farn Lei,1 Emilia S. Olson,2 Qun Cheng,3 Benedict Pereira,1 Lifu Zhao,1 Roger Y. Tsien,2,4,5 and Patrick D. Lyden1,3 1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California 90048, and Departments of 2Pharmacology, 3Neuroscience, 4Chemistry and Biochemistry, and 5Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093
منابع مشابه
Thrombin activity associated with neuronal damage during acute focal ischemia.
Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawley rats by occluding the middle cerebral artery. Intra-arterial thrombin infusion during ischemia significantly increased vascular disruption and c...
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Evidence suggests that thrombin, a blood coagulation serine protease, mediates neuronal injury in experimental cerebral ischemia. Here, we test the hypothesis that nafamostat mesilate, a serine protease inhibitor, may ameliorate ischemia-induced neuronal damage through thrombin inhibition after ischemic stroke. Focal ischemia was induced in adult Sprague-Dawley rats by occlusion of the middle c...
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تاریخ انتشار 2012